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Combining high-content imaging and phenotypic classification analysis of senescence-associated beta-galactosidase staining to identify regulators of oncogene-induced senescence.
ASSAY and Drug Development Technologies
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CellProfiler Analyst: interactive data exploration, analysis and classification of large biological image sets.
Bioinformatics
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A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.
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Advances in predictive toxicology for discovery safety through high content screening.
Chemical research in toxicology
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Comprehensive drug testing of patient-derived conditionally reprogrammed cells from castration-resistant prostate cancer.
European Urology
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Genome-wide RNAi screening identifies protein modules required for 40S subunit synthesis in human cells.
Cell Reports
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Nature Genetics
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Evolution of robustness to protein mistranslation by accelerated protein turnover.
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Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane.
The Journal of Cell Biology
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The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.
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Influenza A virus uses the aggresome processing machinery for host cell entry.
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Genome-wide siRNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration.
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Increasing the content of high-content screening: An overview.
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High-content analysis of sequential events during the early phase of influenza A virus infection.
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Novel role of Cul3 in late endosome maturation
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Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion.
PLoS Pathogens
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Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.
Cell
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Histone deacetylase 8 is required for centrosome cohesion and influenza A virus entry.
PLoS Pathogens
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A protein inventory of human ribosome biogenesis reveals an essential function of Exportin 5 in 60S subunit export.
PLoS Biology